Peptides have become a buzzword in the wellness world—but not all peptides are created equal. While some are used in clinical settings to treat serious conditions, others are found in everyday supplements designed to support hydration, energy, or recovery.
Two terms you’ll hear often are therapeutic peptides and bioactive peptides. Understanding the difference between the two isn’t just about science—it’s about knowing what kind of support your body needs, and which options are safe, accessible, and right for your goals.
What Are Therapeutic Peptides?
Therapeutic peptides are lab-created peptides used in medical treatments. These peptides are usually administered via injection under the supervision of a healthcare provider, and they’re regulated as prescription drugs.
They’re designed to mimic or influence the body’s hormones, enzymes, or signaling pathways in a highly targeted way. Therapeutic peptides may be used to:
- Improve hormone balance (like growth hormone or insulin analogs)
- Support immune function
- Accelerate tissue repair or healing
- Aid in weight loss or metabolic regulation
Examples include:
- Semaglutide (used for blood sugar control and weight loss)
- BPC-157 (known for gut and tissue repair support)
- Thymosin alpha-1 (supports immune function)
Because they may have strong physiological effects, therapeutic peptides are often closely monitored and can come with side effects or specific usage protocols.
What Are Bioactive Peptides?
Bioactive peptides are naturally occurring or plant-derived peptides found in certain foods or dietary supplements. Unlike therapeutic peptides, these are typically taken orally and are used to support the body’s natural functions, not override or replace them.
Bioactive peptides are best known for their ability to communicate with cells, triggering processes related to hydration, energy production, tissue repair, and more. Because they’re shorter and thought to be easier for the body to absorb, they may pass through the gut and interact with key systems.
Common uses for bioactive peptides include:
- Supporting muscle recovery
- Promoting hydration and electrolyte balance
- Enhancing mood, focus, and clarity
- Assisting with metabolic support and energy
One example of this approach is the Bioactive Precision Peptides™ used in MAKE Wellness products. These peptides are plant-derived, designed for daily use, and are formulated to work with your body—not force it into a specific hormonal state.
Key Differences Between Therapeutic and Bioactive Peptides
While both types of peptides work by communicating with the body’s cells, the way they’re used, regulated, and experienced couldn’t be more different. Here’s how they compare:
The biggest difference comes down to intent and intensity. Therapeutic peptides aim to treat, while bioactive peptides are formulated to support—making them more accessible to the everyday consumer without requiring a diagnosis or medical supervision.
Related: What Are Peptides Used For?
Which One Is Right for You?
The right type of peptide depends entirely on your goals.
If you’re working with a medical provider to treat a specific condition, therapeutic peptides may be the right path under supervision. These are powerful tools that should be used with proper guidance and monitoring.
But if you’re looking for everyday support—more energy, better recovery, improved hydration, or enhanced focus—bioactive peptides may offer a more approachable, low-cost option. They’re designed to work with your body, not override it, making them ideal for long-term wellness routines.
Brands like MAKE Wellness are bringing this science into daily life with clean, plant-based formulas built around Bioactive Precision Peptides™. No prescriptions, no needles—just targeted support you can actually stick with.
Want to dive deeper into how these peptides work? Don’t miss What Are Bioactive Precision Peptides? and Are Plant-Based Peptides Effective?
Want to try them out? Visit MAKE Wellness today!
These statements have not been evaluated by the Food and Drug Administration. The contents of this article, made available via Holistic Fit LLC, are for informational purposes only and do not constitute medical advice. The Content presented here is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. If you think you may be suffering from any medical condition, you should seek immediate medical attention. You should never delay seeking medical advice, disregard medical advice, or discontinue medical treatment because of information provided by Holistic Fit LLC. Reliance on any information provided by this article is solely at your own risk. The author is not a licensed medical professional. References to specific products, research, or external websites are for informational purposes only and do not constitute endorsements or recommendations. Individual results may vary. Readers are encouraged to consult updated sources and verify information as scientific knowledge evolves. And, of course, never use a new product, herb or essential oil without first reading the label, doing your research, or checking with a local expert.
Trina Krug is a Holistic Nutritionist, Integrative Health Coach and host of the Carbless Conversations Podcast. With a Master’s Degree in Complementary and Alternative Medicine, her single mission in life is to facilitate self-healing in herself and those around her through awareness, lifestyle shifts and low-carb eating. As a current Doctor of Science student, she continues her studies in functional nutrition.